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Video: Watch Cryptococcus Meningitis Infect Transparent Zebrafish

Cryptococcus Meningitis Infect Transparent Zebrafish
Transparent Zebrafish Infected by Cryptococcus Meningitis
Photographed and recorded under a microscope, watch Cryptococcus Meningitis fungi (red) infect the transparent body of Zebrafish. Watch the Cryptococcus Meningitis (fungi) red fluorescent tracer as it moves through the larval tissue, blood vessels and then into the brain. Blue macrophages try chasing the red infection to devour it, as it spreads through and around green blood vessels.
Cryptococcus Meningitis Infect Transparent Zebrafish
Cryptococcus Meningitis Infects Transparent Zebrafish
Scientists at Duke Medicine are using these real time videos to watch the Cryptococcus move from the lungs into the bloodstream and through the blood-brain barrier of a transparent Zebrafish. The reason Zebrafish are being used is, that they are easier to reproduce and cost less than a mouse or larger mammal. Some of the drawbacks to studying infections in the Zebrafish larvae is their body temperatures are much cooler and they have no lungs, which is where Cryptococcus would enter into human body. Zebrafish are also being used to study other human diseases and bacterias like tuberculosis(TB).

Watch Cryptococcus Meningitis Infect Transparent Zebrafish, moving from the lungs to the brain in the video below.


 

Weak immune systems are one mostly affected by airborne Cryptococcus Meningitis which could become deadly if not treated right away. It is important to see a professional admittedly if you have been exposed to the infected or show Meningitis Symptoms. This crippling brain disease mostly attacks people with weak immune systems and people with HIV/AIDS which results in nearly 625,000 deaths worldwide each year. via CDC




highlighted comments from the research investigation:
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  "What's impressive is that, unlike in a mouse or rabbit, you can actually see the organism producing disease in the live animal," 

   "Our hope is that by creating this system, we can continue our own investigations into other harmful organisms, and that other scientists worldwide can adapt our zebrafish model to investigate the diseases that are priorities in their communities," 

  "Day-by-day, it's growing and moving throughout the body. You can't see this anywhere else."
 
-- John R. Perfect, M.D., chief of the division of infectious diseases at Duke University School of Medicine.
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   "This model will allow researchers to screen the whole organism while it is living with an infection," 

   "It will allow us to screen libraries of drug compounds relatively quickly. We can also develop and test mutant strains of Cryptococcus in these larvae. This can teach us which factors play a role in infection and those could be therapeutic targets in the future." 

--Co-author David Tobin, Ph.D., assistant professor in molecular genetics and microbiology and immunology at Duke.
_________________________________________________________________________________

Source: mBio - Journal of the American Society of Microbiology 
Image/Credit: Stefan Oehlers/Duke University Medical Center
Via: medicaldaily.com

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